Search results

Brundin P, Karlsson J, Emgård M, Kaminski Schierle GS, Hansson O, Petersén Å and Castilho RF.Cell Transplantation 9: 179-195 (2000)AbstractNeural transplantation is developing into a therapeutic alternative in Parkinson's disease. A major limiting factor is that only 3-20% of grafted dopamine neurons survive the procedure. Recent advances regarding how and when the neurons die indicate that events

https://www.huntington-research.lu.se/improving-survival-grafted-dopaminergic-neurons-review-over-current-approaches - 2026-06-03

Hansson O, Petersén Å, Leist M, Nicotera P, Castilho RF and Brundin P.Proceedings of the National Academy of Sciences USA 96: 8727-8732 (1999)AbstractHuntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant HD gene mediates a slowly progressing striatal neuro

https://www.huntington-research.lu.se/transgenic-mice-expressing-huntingtons-disease-mutation-are-resistant-quinolinic-acid-induced - 2026-06-03

Petersén Å, Emgård M and Brundin P.Brain Research Bulletin 50: 275-281 (1999)AbstractThe survival of grafted embryonic striatal tissue, dissected from the lateral ganglionic eminence, depends on the status of the host striatum. We found significantly larger volumes of surviving graft tissue and of striatal-like tissue (P-zone) within the graft, when the host striatum had been subjected to an excit

https://www.huntington-research.lu.se/impact-preceding-excitotoxic-lesion-and-treatment-ciliary-neurotrophic-factor-striatal-graft - 2026-06-03

Petersén Å and Brundin P.Experimental Neurology 160: 402-412 (1999)AbstractCiliary neurotrophic factor (CNTF) has a protective effect on the striatum in animal models of Huntington's disease. However, the mechanism through which it exerts its effect is not clear. In this study, we show that there is a concentration-dependent direct protective effect of CNTF against N-methyl-D-aspartate-mediated ex

https://www.huntington-research.lu.se/effect-cntf-and-calcium-ionophore-a23187-induced-death-cultured-embryonic-stratal-neurons - 2026-06-03

Petersén Å, Mani K and Brundin P.Experimental Neurology 157: 1-18 (1999)AbstractWe review recent advances regarding the pathogenesis of Huntington's disease (HD). This genetic neurodegenerative disorder is caused by an expanded CAG repeat in a gene coding for a protein, with unknown function, called huntingtin. There is selective death of striatal and cortical neurons. Both in patients and a trans

https://www.huntington-research.lu.se/recent-advances-pathogenesis-huntingtons-disease - 2026-06-03

Baldo B, Gabery S, Soylu-Kucharz R, Cheong RY, Henningsen JB, Englund E, McLean C, Kirik D, Halliday G and Petersén Å.Neuropathology and Applied Neurobiology 45 (4): 361-379 (2019)AbstractAIMS:Metabolic dysfunction is involved in modulating the disease process in Huntington disease (HD) but the underlying mechanisms are not known. The aim of this study was to investigate if the metabolic regulator

https://www.huntington-research.lu.se/sirt1-increased-affected-brain-regions-and-hypothalamic-metabolic-pathways-are-altered-huntington - 2026-06-03

Brundin P, Petersén Å and Hansson O.Journal of Neurosurgery 90: 804-806 (1999)No abstract available; this is a letter to the editor.The letter 

https://www.huntington-research.lu.se/graft-survival - 2026-06-03

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA and Jakobsson J.Cell Reports 24(6): 1397-1406 (2018)AbstractMany neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences o

https://www.huntington-research.lu.se/huntingtin-aggregation-impairs-autophagy-leading-argonaute-2-accumulation-and-global-microrna - 2026-06-03

Fjalldal S, Follin C, Svärd D, Rylander L, Gabery S, Petersen Å, Van Westen D, Sundgren P, Bjorkman-Burtscher I, Lätt J, Ekman B, Johanson A and Erfurth EM.European Journal of Endocrinology 178 (6): 577-587 (2018)AbstractCONTEXT:Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.OBJECTIVE:To determine whether th

https://www.huntington-research.lu.se/microstructural-white-matter-alterations-and-hippocampal-volumes-are-associated-cognitive-deficits - 2026-06-03

Gawlik KI1, Harandi VM2, Cheong RY3, Petersén Å3, Durbeej M2.1Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.2Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.3Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.Matrix Biology 70: 36-79 (20

https://www.huntington-research.lu.se/laminin-a1-reduces-muscular-dystrophy-dy2j-mice - 2026-06-03

Vercruysse P, Vieau D, Blum D, Petersén Å and Dupuis L.Frontiers in Molecular Neuroscience 11:2 (2018)AbstractNeurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington's disease (HD), or co

https://www.huntington-research.lu.se/hypothalamic-alterations-neurodegenerative-diseases-and-their-relation-abnormal-energy-metabolism - 2026-06-03

Please note, that all links on this page open a new webpage. Knut and Alice Wallenberg FoundationThrough the research program Wallenberg Clinical Scholars, the Knut and Alice Wallenberg Foundation are funding 24 of the foremost clinical researchers in Sweden. Almost SEK 800 million are used for funding over ten years. Åsa Petersén was appointed Wallenberg Clinical Scholar 2020 and will receive SEK

https://www.huntington-research.lu.se/funding - 2026-06-03

Congratulations and welcome to the course FKVB21! Welcome to the Political Science Department at Lund University. Please see the information below that you need to know in order to secure our offer. It is important that you read the information thoroughly. Secure your place – important deadline You must accept the offer no later than 20 July at 23:59 (Swedish time).If you do not accept the offer b

https://www.svet.lu.se/en/education/new-student-admission-information/war-and-peace-israeli-palestinian-conflict - 2026-06-03

Congratulations and welcome to the course STVP34 Welcome to the Political Science Department at Lund University. Please see the information below that you need to know in order to secure our offer. It is important that you read the information thoroughly. Secure your place – important deadline You must accept the offer no later than 20 July at 23:59 (Swedish time).If you do not accept the offer by

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-eu-law - 2026-06-03

Congratulations and welcome to the course STVP37! Welcome to the Political Science Department at Lund University. Please see the information below that you need to know in order to secure our offer. It is important that you read the information thoroughly. Secure your place – important deadline You must accept the offer no later than 20 July at 23:59 (Swedish time).If you do not accept the offer b

https://www.svet.lu.se/en/education/new-student-admission-information/europe-global-affairs - 2026-06-03

Congratulations and welcome to the course STVM23! Welcome to the Political Science Department at Lund University. Please see the information below that you need to know in order to secure our offer. It is important that you read the information thoroughly Secure your place – important deadline You must accept the offer no later than 20 July at 23:59 (Swedish time).If you do not accept the offer by

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-masters-two-years-thesis-european-affairs - 2026-06-03

Congratulations and welcome to the course STVN17! Welcome to the Political Science Department at Lund University. Please see the information below that you need to know in order to secure our offer. It is important that you read the information thoroughly. Secure your place – important deadline You must accept the offer no later than 20 July at 23:59 (Swedish time).If you do not accept the offer b

https://www.svet.lu.se/en/education/new-student-admission-information/power-politics-and-environment - 2026-06-03

Congratulations and welcome to the course STVN13! Welcome to the Political Science Department at Lund University. Please see the information below that you need to know to secure our offer. You must read the information thoroughly. Secure your place – important deadline You must accept the offer no later than 20 July at 23:59 (Swedish time).If you do not accept the offer by this deadline, it will

https://www.svet.lu.se/en/education/new-student-admission-information/war-and-peace-world-transition - 2026-06-03

Congratulations and welcome to the course STVB30! Welcome to the Political Science Department at Lund University. Please see the information below that you need to know in order to secure our offer. It is important that you read the information thoroughly. Secure your place – important deadline You must accept the offer no later than 20 July at 23:59 (Swedish time).If you do not accept the offer b

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-fieldwork-internship-and-research-overview - 2026-06-03

Congratulations and welcome to the course STVC76! Welcome to the Political Science Department at Lund University. Please see the information below that you need to know in order to secure our offer. It is important that you read the information thoroughly. Secure your place – important deadline You must accept the offer no later than 20 July at 23:59 (Swedish time).If you do not accept the offer b

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-comparative-politics - 2026-06-03